GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs9321659 | 1 | rs6931884 | chr6:100158873 | USP45 | chr6:99880184-99963312:- | 0.21 | 3.42 | 0.000687 | Menarche (age at onset) |
| THCA | cis | rs1056667 | 1 | rs6932156 | chr6:26571506 | BTN2A3 | chr6:26422317-26431927:+ | 0.18 | 4.22 | 2.98E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs6932156 | chr6:26571506 | HCG11 | chr6:26521934-26527610:+ | -0.21 | -4.11 | 4.7E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs6932156 | chr6:26571506 | HMGN4 | chr6:26538572-26547162:+ | -0.16 | -4.16 | 3.71E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs6932156 | chr6:26571506 | LOC100270746 | chr6:26987146-26988085:- | -0.14 | -3.36 | 0.000857 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs6932156 | chr6:26571506 | ZNF322A | chr6:26634612-26659963:- | -0.16 | -4.59 | 5.75E-6 | Educational attainment |
| THCA | cis | rs6932590 | 1 | rs6932590 | chr6:27248931 | BTN3A2 | chr6:26365398-26378546:+ | -0.27 | -6.26 | 8.7E-10 | Schizophrenia |
| THCA | cis | rs1853665 | 1 | rs6933094 | chr6:150297603 | RAET1K | chr6:150319157-150326280:- | 0.68 | 6.06 | 2.81E-9 | Radiation response |
| THCA | cis | rs1853665 | 1 | rs6933094 | chr6:150297603 | ULBP1 | chr6:150285143-150294844:+ | -0.49 | -7.46 | 4.2E-13 | Radiation response |
| THCA | cis | rs1853665 | 1 | rs6933094 | chr6:150297603 | ULBP2 | chr6:150263136-150270366:+ | 0.64 | 6.91 | 1.57E-11 | Radiation response |
| THCA | cis | rs943466 | 1 | rs6933174 | chr6:33751003 | LEMD2 | chr6:33738991-33756906:- | 0.25 | 4.99 | 8.49E-7 | Body mass index |
| THCA | cis | rs1056667 | 1 | rs6933176 | chr6:26540178 | BTN2A3 | chr6:26422317-26431927:+ | 0.18 | 4.32 | 1.9E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs6933176 | chr6:26540178 | HCG11 | chr6:26521934-26527610:+ | -0.22 | -4.34 | 1.75E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs6933176 | chr6:26540178 | HMGN4 | chr6:26538572-26547162:+ | -0.16 | -4.03 | 6.38E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs6933176 | chr6:26540178 | ZNF322A | chr6:26634612-26659963:- | -0.14 | -3.91 | 0.000106 | Educational attainment |